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Dynamic Biomaterial: A Platform for Biomedical Applications With Multiple Preparation Strategies
Hanbing Duan1, Shuo Feng1,2, Yonggang Lv1
1State Key Laboratory of New Textile Materials and Advanced Processing, Wuhan Textile University, Wuhan, P. R. China.
Macromolecular Rapid Communications
|July 26, 2026
Summary
Dynamic biomaterials adapt to physiological changes via controllable property shifts. This review explores their mechanisms, applications in tissue engineering and drug delivery, and future potential.
Area of Science:
- Biomaterials Science
- Materials Engineering
- Biomedical Engineering
Background:
- Conventional static biomaterials have fixed properties, limiting adaptation to dynamic physiological environments.
- Dynamic biomaterials offer programmable physicochemical changes in response to stimuli, enhancing spatiotemporal adaptability.
Purpose of the Study:
- To systematically review dynamic biomaterials from a physical-cue-centered perspective.
- To analyze responsive mechanisms, preparation strategies, and stimuli (light, temperature, pH, ions, magnetic fields).
- To highlight biomedical applications and discuss future perspectives.
Main Methods:
- Focus on stimulus-responsive changes in stiffness, surface morphology, and shape programmability.
- Summarize and critically analyze responsive mechanisms and preparation strategies.
- Review representative stimuli and their effects on dynamic biomaterials.
Main Results:
- Dynamic biomaterials exhibit tunable properties like stiffness and shape in response to various stimuli.
- Key applications include tissue engineering, drug delivery, minimally invasive therapy, and intelligent biomedical devices.
- Identified challenges include biosafety, mechanical durability, manufacturability, and clinical translation.
Conclusions:
- Dynamic biomaterials represent a significant advancement over static ones, offering superior adaptability.
- Future research should focus on multifunctional, multi-stimuli-responsive, and spatiotemporally programmable materials for enhanced biomedical applications.
