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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

Published on: January 21, 2020

Synthesis, Characterization, and Fluorescence Application of Indole-Based Isofunctional NAD+ Analogs

Danqi Li1, Bo Zhuang1, Ran-Ran Feng1

  • 1Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.

Chembiochem : a European Journal of Chemical Biology
|July 26, 2026
PubMed
Summary

Researchers developed two fluorescent nicotinamide adenine dinucleotide (NAD+) analogs, 4CNI-NAD+ and 4CN7AI-NAD+, to overcome challenges in studying NAD+-dependent reactions. These analogs enable fluorescence-based monitoring of enzymatic processes involving NAD+ and NADH.

Keywords:
NAD analogNAD reactionfluorescence reporternicotinamide adenine dinucleotide (NAD)

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