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Published on: April 6, 2019
Nudiloid Z, a New Labdane-Type Diterpenoid From Callicarpa nudiflora With Anti-Inflammatory Activity
Qi Li1,2, Bo Li1, Yan-Ling Tang1
1Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, Institute of International Rivers and Eco-Security, School of Pharmacy, School of Chemical Science and Technology, Yunnan University, Kunming, China.
Abstract:
A new labdane-type diterpenoid, Nudiloid Z (1), together with twelve known compounds (2-13), were isolated and purified from the stems and leaves of Callicarpa nudiflora. Compound 1 possesses a three-membered epoxide ring at C-12 and C-13. The planar structure and absolute configuration of 1 were elucidated by comprehensive spectroscopic analyses. The inhibitory effects of compounds 1-3 and 8 on lactate dehydrogenase (LDH) release in J774A.1 cell was evaluated. The results indicated that compound 1 exhibited significant anti-inflammatory activity, with an inhibitory concentration 50% (IC50) value of 3.30 ± 0.47 µM on LDH release and reduced the Interleukin 1β (IL-1β) levels in a dose-dependent manner.