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Updated: Aug 5, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Iodine-Catalyzed Carbonyl Desaturation: A One-Pot Synthesis of Flavones
Heng-Xin Mao1, Bao-Yin Zhao1, Li-Gang Kou1
1Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an710069, China.
Abstract:
Carbonyl desaturation represents a fundamental chemical transformation widely practiced in organic synthesis. Transition metal-catalyzed direct α,β-desaturation of carbonyl compounds has been well developed. Herein, we disclose an efficient one-pot synthesis of flavones from phenolic ketones via double iodine-catalyzed α,β-dehydrogenation and an oxa-Michael addition. This protocol is a metal-free approach to carbonyl desaturation with nontoxic DMSO as both the solvent and oxidant, which is especially beneficial for the synthesis of pharmaceutical compounds. Mechanistic studies suggest that the transformation proceeds via a radical pathway.
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