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Tuning Core Fluidity in Emulsion Nanoparticles for Stable and Transition-Metal-Free Responsive 19F MRI Probes
Shiho Sugiura1, Kodai Fukushima1, Tomoya Yamamoto1,2,3
1Department of Applied Chemistry, Graduate School of Engineering, The University of Osaka, 2-1, Yamadaoka, 5650871Suita, Osaka, Japan.
Journal of the American Chemical Society
|July 27, 2026
Summary
Researchers developed novel 19F MRI probes using solid lipids for enhanced stability and controlled fluidity. These probes offer improved in vivo imaging and responsive signal activation without toxic metals.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Magnetic Resonance Imaging
Background:
- 19F MRI probes are valuable for in vivo imaging due to their lack of background signal.
- Current nanoemulsion probes face stability challenges and limited control over surface properties.
- Existing responsive probes often rely on toxic paramagnetic metals.
Purpose of the Study:
- To develop stable and responsive 19F MRI probes with tunable physicochemical properties.
- To overcome the limitations of conventional nanoemulsion probes and metal-based responsive agents.
- To establish a new design paradigm for 19F MRI agents through internal structural regulation.
Main Methods:
- Incorporation of solid lipids into the core of emulsion-based 19F MRI probes.
- Simultaneous control of emulsion stability and internal fluidity without external coatings.
- Development of ROS-responsive probes utilizing fluidity changes to activate 19F MR signals.
Main Results:
- Achieved enhanced emulsion stability and controlled internal fluidity.
- Demonstrated clear in vivo 19F MRI visualization with minimal accumulation and rapid clearance (within 1 day).
- Successfully developed a metal-free responsive probe activated by ROS-induced fluidity changes.
Conclusions:
- The novel emulsion-based 19F MRI probes offer improved stability and tunable responsiveness.
- Internal structural regulation provides a versatile platform for designing advanced imaging agents.
- This strategy enables metal-free visualization of biomarker responses, advancing diagnostic capabilities.
