Related Experiment Video
Updated: Aug 5, 2026
08:01
Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
Published on: March 22, 2012
Risk Factors for Mortality Associated With Influenza Infection in Patients With Hematologic Malignancies: A
Setayesh Sindarreh1, Seyed Amirhossein Dormiani Tabatabaei1, Mehran Sharifi1
1Cancer Prevention Research Center Isfahan University of Medical Sciences Isfahan Iran.
Health Science Reports
|July 27, 2026
Summary
Patients with hematologic malignancies (HMs) face severe influenza risks. This study found multiple myeloma (MM), acute myeloid leukemia (AML), comorbidities, and lower respiratory tract infections (LRTIs) significantly predict mortality in these patients.
Area of Science:
- Hematology
- Infectious Diseases
- Oncology
Background:
- Hematologic malignancies (HMs) place patients at high risk for severe influenza complications.
- Influenza infection poses a significant threat to immunocompromised individuals undergoing cancer treatment.
Purpose of the Study:
- To investigate influenza infection outcomes in patients with HMs.
- To identify risk factors associated with influenza-related mortality in this vulnerable population.
Main Methods:
- A cross-sectional descriptive observational study of 90 patients with confirmed influenza and HMs.
- Data collected included demographics, cancer details, influenza type, symptoms, clinical findings, and outcomes (ICU admission, mortality).
Main Results:
- Influenza A was the predominant infection (80%).
- Risk factors for ICU admission included older age, comorbidities, lower respiratory tract infections (LRTIs), and specific malignancies (multiple myeloma [MM], chronic myelogenous leukemia [CML], acute myeloid leukemia [AML]).
- Mortality was higher in patients with MM or AML, comorbidities, and LRTIs.
Conclusions:
- MM, LRTIs, and comorbidities are identified as strong predictors of mortality in HMs patients with influenza.
- These findings highlight the critical need for vigilant monitoring and management of influenza in this high-risk group.
Related Concept Videos
01:27Influenza
Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
01:27Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...