Association between triglyceride-glucose index and sarcopenia: a meta-analysis
Shuying Zou1, Yuzhou Li2, Xiangnan Zhu2
1School of Nursing, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Peerj
|July 27, 2026
Summary
The triglyceride-glucose (TyG) index is significantly associated with sarcopenia in the elderly. Higher TyG index levels correlate with an increased prevalence of sarcopenia, suggesting its utility in early detection.
Area of Science:
- Gerontology
- Metabolic Health
- Nutritional Epidemiology
Background:
- Population aging is increasing sarcopenia prevalence.
- The triglyceride-glucose (TyG) index shows a correlation with sarcopenia.
- This study investigates the TyG index's association with sarcopenia.
Purpose of the Study:
- To systematically evaluate the association between the triglyceride-glucose (TyG) index and sarcopenia.
- To quantify the risk of sarcopenia based on TyG index levels.
- To explore factors influencing the TyG index-sarcopenia relationship.
Main Methods:
- Systematic literature search of PubMed, Web of Science, Embase, and Cochrane Library.
- Meta-analysis of 14 studies including 82,798 participants.
- Random-effects model used to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs).
Main Results:
- A significant association was found between the TyG index and sarcopenia (OR = 2.15).
- Sarcopenia risk increased across TyG index quartiles (Q2-Q4).
- The TyG-BMI index showed a stronger, dose-dependent association with sarcopenia.
Conclusions:
- The TyG index is a significant indicator for sarcopenia.
- Elevated TyG index levels are linked to higher sarcopenia prevalence.
- The TyG index may serve as a valuable tool for sarcopenia screening and early intervention.