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From Antibody Drugs to RNA Interference and Nanotherapy: The Evolution and Integration of Targeted Strategies in

Songlin Wang1, Yinhong Dong1, Lan Ma2,3,4

  • 1Zhongxiang People's Hospital, Zhongxiang, People's Republic of China.

International Journal of Nanomedicine
|July 27, 2026
PubMed

Insights

Gastric cancer therapies are evolving beyond single treatments. Future strategies combine antibody drugs, RNA interference (RNAi), and nanocarriers for precise gene regulation and improved patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biotechnology

Background:

  • Gastric cancer remains a major global cause of cancer mortality.
  • Current targeted therapies show promise but face limitations like resistance and low response rates.

Purpose of the Study:

  • To review advancements in antibody drugs, RNA interference (RNAi), and nanocarriers for gastric cancer treatment.
  • To explore the potential of these modalities in precise gene regulation and overcoming therapeutic challenges.

Main Methods:

  • Review of current literature on antibody-based therapies (anti-HER2, VEGFR2 inhibitors, Claudin 18.2, PD-1/PD-L1).
  • Analysis of RNAi mechanisms, challenges (degradation, delivery, off-target effects), and potential applications.
  • Examination of nanocarrier systems (LNPs, micelles, mesoporous silica) for targeted delivery of antibodies and siRNA.

Main Results:

  • Biomarker-selected antibody therapies improve survival but have limited efficacy in unselected populations.
  • RNAi offers potential for reversing chemoresistance and reprogramming the tumor microenvironment but requires improved delivery and stability.
  • Nanocarriers enhance targeted delivery, penetration, and controlled release of therapeutics, addressing delivery challenges.

Conclusions:

  • The future of gastric cancer therapy involves a shift towards precise gene regulation and combination strategies.
  • A five-part approach integrating antibody targeting, RNA silencing, nanocarrier delivery, AI-driven decisions, and immune remodeling is proposed.
Keywords:
RNA interferencegastric cancernanoparticlesshRNAsiRNAtarget therapy

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