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Updated: Aug 5, 2026
12:24
A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
Metabolic Reprogramming-Targeted Therapeutic Strategies in Primary Liver Cancer: A Bibliometric and Visualized
Qiwei Yang1, Lin Yu1, Yishan Peng1
1The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People's Republic of China.
Journal of Hepatocellular Carcinoma
|July 27, 2026
Summary
Research on metabolic reprogramming in primary liver cancer (PLC) is rapidly expanding. Current focus is on glucose, lipid, and amino acid metabolism, with growing interest in immunotherapy resistance and combination therapies.
Area of Science:
- Oncology
- Metabolic Research
- Therapeutics
Background:
- Metabolic reprogramming is a key feature of primary liver cancer (PLC), including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA).
- Understanding the global research trends and collaboration patterns in metabolism-targeted therapies for PLC is crucial.
Purpose of the Study:
- To analyze the global research landscape, collaboration patterns, and evolving hotspots of metabolism-targeted therapeutic strategies in PLC.
- To provide an overview of the research trends from 2005 to 2025.
Main Methods:
- Bibliometric and visualization analyses were conducted on publications from the Web of Science Core Collection (2005-2025).
- Tools such as VOSviewer, CiteSpace, and RStudio were used to analyze publication trends, collaboration networks, and keyword evolution.
Main Results:
- A total of 1,316 publications from 62 countries were analyzed, with China leading in publications and the US in citation influence.
- Research primarily focuses on glucose, lipid, and amino acid metabolism, and tumor microenvironment alterations.
- Increasing attention is given to immunotherapy resistance, tumor microenvironment remodeling, and metabolism-based combination therapies, with significant international collaboration, especially between China and the US.
Conclusions:
- Research on metabolism-targeted therapies for PLC has grown significantly over the past two decades.
- Current hotspots include metabolic reprogramming and tumor microenvironment-associated therapeutic approaches.
- These findings offer a comprehensive overview to guide future research and therapeutic development in PLC.
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