A Case of Isolated Epstein-Barr Virus Hepatitis With Jaundice

Epstein-Barr virus (EBV), presenting as infectious mononucleosis (IM), affects almost all people by age 20. It has several systemic manifestations that are associated with pharyngitis and fever. We present a rare presentation of EBV infection manifesting as hepatitis and jaundice without prior IM symptoms. A 46-year-old female presented with abdominal pain and jaundice. Laboratory findings showed elevated liver enzymes and bilirubin. There was no evidence of other diseases on laboratory findings, imaging, or symptoms. EBV IgM was the only laboratory-positive value. The patient continued symptomatic treatment and fully recovered within about 10 months. EBV manifesting as isolated hepatitis occurs rarely in the population. Cases of hepatitis not preceded by IM have not been reported previously.