Facile synthesis of isoxazoline-bispirooxindoles via the 1,3-dipolar cycloaddition of nitrile oxides with isoindigos
Jian Wang1, Song Hu1, Chengjian Cao2
1Laboratory of Green Catalysis of Higher Education Institutes of Sichuan, College of Chemistry and Environmental Engineering, Sichuan University of Science & Engineering, Zigong 643000, China. yu_longli@suse.edu.cn.
Abstract:
An efficient 1,3-dipolar cycloaddition of nitrile oxides and isoindigos has been disclosed, enabling straightforward access to diverse isoxazoline-bispirooxindoles with vicinal quaternary spirocenters in moderate to excellent yields with high diastereoselectivity. This protocol exhibits a broad substrate scope, excellent functional group compatibility, mild reaction conditions, and operational simplicity. Moreover, a gram-scale reaction followed by subsequent transformations further highlights the practical utility of this approach.
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