Related Experiment Video
Updated: Aug 5, 2026
10:18
Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing
Published on: October 16, 2018
Next step after PrEP: HIV prevention pathways among former PrEP users disengaged from care
Inge J M Willemstein1,2, Janneke C M Heijne1,2, Kenneth Yap1
1Department of Infectious Diseases, Public Health Service Amsterdam.
AIDS (London, England)
|July 27, 2026
Summary
Most individuals stopped pre-exposure prophylaxis (PrEP) care due to reduced HIV risk. However, some still needing PrEP discontinued use, highlighting a need for re-engagement in HIV prevention services.
Area of Science:
- Public Health
- HIV Prevention
- Sexual Health
Background:
- Pre-exposure prophylaxis (PrEP) is a key HIV prevention strategy.
- Disengagement from PrEP care can lead to unmet prevention needs.
- Understanding reasons for discontinuation is crucial for service improvement.
Purpose of the Study:
- To investigate HIV prevention pathways after PrEP care disengagement.
- To identify factors influencing continued PrEP use or non-use.
- To inform strategies for improving PrEP services at the Center of Sexual Health in Amsterdam (CSHA).
Main Methods:
- Cross-sectional study involving an online survey of individuals disengaged from PrEP care at CSHA.
- Survey data on discontinuation reasons, continued PrEP use elsewhere, and sexual behavior.
- Analysis using descriptive statistics, thematic analysis, and multivariable Bayesian logistic regression.
Main Results:
- 37.2% of disengaged individuals responded to the survey.
- The primary reason for discontinuation was a perceived reduced need for PrEP due to changes in sexual behavior.
- A significant proportion (33.2%) of respondents who discontinued PrEP at CSHA could still benefit from it, with 13.4% not using any HIV prevention strategy.
Conclusions:
- While many PrEP discontinuations align with periods of lower HIV risk, a notable percentage of individuals who could benefit from PrEP are not using it after disengaging from care.
- Lost-to-follow-up individuals and those aged 35 or younger showed higher odds of not using PrEP elsewhere.
- There is a critical need to support individuals for re-engagement in HIV prevention care to mitigate HIV acquisition risk.
Related Concept Videos
01:30Preventive Healthcare Services
Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
01:26Levels of Health Promotion and Illness Prevention
Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
In primary prevention, actions taken before disease onset prevent the disease from...
In primary prevention, actions taken before disease onset prevent the disease from...
01:22Healthcare Associated Infections II: Preventive Measures
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
01:30Community Based Intervention
Community-based interventions in mental health represent a paradigm shift from institution-centered care to treatments embedded within the fabric of local communities. By prioritizing inclusion and leveraging existing societal structures, this approach fosters a supportive environment conducive to addressing mental health challenges while promoting individual dignity and agency.
Foundations of Community Mental Health Programs
Central to the success of community-based interventions is the...
Foundations of Community Mental Health Programs
Central to the success of community-based interventions is the...
01:10Retrovirus Life Cycles
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...
01:31Discharge Summary Forms
The discharge summary is crucial as it enables a smooth transition from a healthcare facility to a patient's home or another care setting. This critical document facilitates seamless continuity of care, ensuring patients receive the necessary support and attention.
Here's a detailed look at the key components and guidelines for preparing a discharge summary:
Here's a detailed look at the key components and guidelines for preparing a discharge summary: