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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

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Published on: January 28, 2020

Predictors and Prognostic Significance of Cardiac Damage Progression in Non-Severe Aortic Stenosis

Benjamin Mothibe Bussmann1,2, Nicholas Johnson1, Nishta Jankee Ramjee1

  • 1Oxford Heart Centre, Oxford University Hospitals NHS Trust, Headley Way, Oxford, OX3 9DU, UK.

European Heart Journal. Cardiovascular Imaging
|July 27, 2026
PubMed

Insights

Cardiac damage is common in early aortic stenosis and progresses over time, driven by comorbidities. This progression independently predicts mortality in patients with non-severe aortic stenosis.

Area of Science:

  • Cardiology
  • Cardiovascular Research
  • Clinical Medicine

Background:

  • Cardiac damage (CD) is prevalent in aortic stenosis (AS) and predicts adverse outcomes.
  • The natural history and progression drivers of CD in early AS are not well understood.
  • This study investigates CD progression in patients with non-severe AS.

Purpose of the Study:

  • To identify predictors of cardiac damage progression in non-severe aortic stenosis.
  • To determine the prognostic significance of cardiac damage progression.
  • To understand the natural history of cardiac damage in early stages of aortic stenosis.

Main Methods:

  • Single-center cohort study with longitudinal follow-up.
  • Evaluation of cardiac damage presence and progression using serial echocardiography.
  • Inclusion of patients with mild or moderate aortic stenosis at baseline.

Main Results:

  • 75% of 1751 patients had baseline cardiac damage; advanced stages (3-4) increased from 24% to 30% over 2.1 years.
  • Comorbidities, atrial fibrillation, and left atrial dilation predicted advanced CD progression, not AS severity.
  • CD progression was an independent predictor of all-cause mortality (aHR 1.35).

Conclusions:

  • Cardiac damage is common and progresses in non-severe AS.
  • Comorbidities and myocardial remodeling drive CD progression.
  • CD progression is an independent predictor of mortality in non-severe AS.
Abstract

Keywords:
Aortic stenosiscardiac damageechocardiography

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