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Red-to-NIR-Fluorescent Graphene Quantum Dots for Biomedical Applications
Shuyi He1, Weichao Liu1, Kang Qin1
1Department of Chemistry, University of South Dakota, Vermillion, SD 57069, USA.
Biosensors
|July 27, 2026
Summary
Red-to-near-infrared (NIR) fluorescent graphene quantum dots (GQDs) offer enhanced biomedical imaging and biosensing. These advanced GQDs overcome limitations of UV-visible fluorescence, enabling deeper tissue penetration and improved signal-to-noise ratios.
Area of Science:
- Materials Science
- Biomedical Engineering
- Nanotechnology
Background:
- Graphene quantum dots (GQDs) possess advantageous physicochemical properties for biomedical use.
- Conventional GQDs emit in the UV-visible spectrum, leading to low signal-to-noise ratios due to biological autofluorescence.
- Extending GQD emission to the red-to-near-infrared (NIR) region is crucial for advanced biomedical applications.
Purpose of the Study:
- To review recent advancements in red-to-NIR-fluorescent GQDs for biomedical applications.
- To highlight synthesis methods, optical properties, and surface engineering strategies for these GQDs.
- To discuss their current and potential future applications in biosensing, bioimaging, and theranostics.
Main Methods:
- Review of literature on synthesis of red-to-NIR-fluorescent GQDs.
- Analysis of optical properties and surface modification techniques.
- Compilation of applications in biosensing, bioimaging, and theranostics.
Main Results:
- GQDs emitting in the red-to-NIR region have been successfully synthesized.
- These red-to-NIR GQDs exhibit properties suitable for enhanced biomedical imaging and biosensing.
- Applications demonstrated include improved resolution, deeper tissue penetration, and reduced autofluorescence interference.
Conclusions:
- Red-to-NIR-fluorescent GQDs represent a significant advancement for biomedical applications.
- Further research into their synthesis, engineering, and therapeutic potential is warranted.
- These nanomaterials hold great promise for future diagnostic and therapeutic strategies.
