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Establishment and Characterization of UTI and CAUTI in a Mouse Model
Published on: June 23, 2015
Gut Colonisation and Multidrug-Resistant Urinary Tract Infections in Hospitalised Kidney Transplant Recipients: A
Laura Loiacono1, Assunta Navarra2, Claudia Rotondo3
1Clinical and Research Infectious Diseases Department, National Institute for Infectious Diseases "Lazzaro Spallanzani", IRCCS, 00149 Rome, Italy.
Antibiotics (Basel, Switzerland)
|July 27, 2026
Summary
Rectal screening for carbapenemase-producing Klebsiella pneumoniae (CP-KP) may indicate a risk for complicated urinary tract infections (cUTIs) in kidney transplant recipients. Further research is needed to confirm this association and guide clinical practice.
Area of Science:
- Nephrology
- Infectious Diseases
- Microbiology
Background:
- Urinary tract infections (UTIs) are common post-kidney transplant complications.
- Multidrug-resistant organisms (MDROs) increasingly cause UTIs in transplant recipients.
- The role of intestinal MDRO colonization in complicated UTIs (cUTIs) is unclear.
Purpose of the Study:
- To investigate the association between intestinal MDRO colonization and cUTIs in kidney transplant recipients.
- To identify risk factors for cUTIs and associated bloodstream infections (BSIs).
- To evaluate the potential of rectal screening for MDROs in risk stratification.
Main Methods:
- Retrospective single-centre study of kidney/kidney-pancreas transplant recipients.
- Analysis of hospitalizations for infectious diseases, with rectal screening for specific MDROs.
- Evaluation of pathogen prevalence, resistance mechanisms, and clinical outcomes.
Main Results:
- cUTIs occurred in 63.1% of admissions; 22.0% had concomitant BSIs.
- Carbapenemase-producing Klebsiella pneumoniae (CP-KP) rectal carriage was more frequent in cUTI patients (31.7% vs. 4.2%).
- CP-KP rectal carriage showed a positive predictive value of 75.0% for CP-KP cUTI etiology.
Conclusions:
- Rectal CP-KP colonization may be a marker for cUTI risk in kidney transplant recipients.
- Study limitations include design and sample size, necessitating larger prospective studies.
- Rectal screening could aid risk stratification, but its role in empirical therapy needs prospective evaluation.
Keywords:
carbapenem-resistant Enterobacteralescarbapenemase-producing Klebsiella pneumoniaecomplicated urinary tract infectionkidney transplantationmultidrug-resistant organismsrectal colonisationMore Related Videos
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