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Phage-Derived Endolysins Targeting Cutibacterium acnes: A Scoping Review
Magdalena Sołtys1, Rafał Kuczma2, Katarzyna Jermakow3
1Students' Scientific Association of Cosmetology, Department of Cosmetology and Aesthetic Dermatology, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 91-151 Łódź, Poland.
Antibiotics (Basel, Switzerland)
|July 27, 2026
Summary
Bacteriophage-derived endolysins show promise for treating acne vulgaris by targeting Cutibacterium acnes. Further research is needed to overcome preclinical limitations for clinical application.
Area of Science:
- Dermatology
- Microbiology
- Biotechnology
Background:
- Acne vulgaris is a common inflammatory skin condition driven by Cutibacterium acnes.
- Antimicrobial resistance necessitates novel therapeutic approaches for acne.
- Bacteriophage endolysins offer a potential selective antimicrobial strategy.
Purpose of the Study:
- To review existing evidence on endolysins targeting C. acnes.
- To assess their antibacterial activity, selectivity, safety, and formulation challenges.
- To evaluate the translational potential of endolysins for acne treatment.
Main Methods:
- Scoping review adhering to PRISMA-ScR guidelines.
- Comprehensive literature search across major scientific databases.
- Inclusion of experimental studies, theses, and patents on C. acnes endolysins.
Main Results:
- Endolysins demonstrated rapid bactericidal activity against C. acnes, including resistant strains.
- Some endolysins showed selectivity, sparing commensal skin bacteria.
- Preclinical data indicate potential, but translational challenges like stability and delivery exist.
Conclusions:
- Phage-derived endolysins are a promising therapeutic avenue for acne vulgaris.
- Current evidence is largely preclinical, requiring further validation.
- Key barriers include formulation stability, delivery, safety, and clinical efficacy demonstration.
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