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Updated: Aug 5, 2026

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A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse
Published on: October 24, 2017
Sonographic Assessment of Fetal Anatomy in the First Trimester: A Comparative Study of Visualization Rates Using Two-
Savoia Fabiana1, La Verde Marco1, Giudicepietro Antonia2
1Department of Obstetrics and Gynecology, University Luigi Vanvitelli, 80138 Naples, Italy.
Clinics and Practice
|July 27, 2026
Summary
Standard 2D ultrasound provides superior visualization of fetal anatomy compared to 3D ultrasound in the first trimester. While 3D ultrasound has potential for specific uses, 2D remains the primary tool for comprehensive fetal assessment.
Area of Science:
- Medical Imaging
- Obstetrics
- Fetal Medicine
Background:
- First-trimester ultrasound is crucial for fetal anatomical assessment.
- Comparing standard 2D ultrasound with single 3D volume acquisition for visualization rates.
Purpose of the Study:
- To compare the visualization rates of fetal anatomical structures using standard 2D ultrasound versus a single 3D volume in the first trimester.
Main Methods:
- Multicenter prospective study involving experienced sonographers.
- Standardized protocol to assess 17 key fetal anatomical structures.
- Included non-anomalous fetuses between 11 + 0 and 13 + 6 weeks gestation.
Main Results:
- 2D ultrasound visualized all 17 structures in 64.85% of fetuses, compared to 35.15% with 3D ultrasound (p=0.001).
- Statistically significant differences in visualization rates were observed for posterior fossa, neck, orbits, nasal bone, lung fields, cardiac axis, bladder, and abdominal wall.
- No significant differences were found for other anatomical portions.
Conclusions:
- Standard 2D ultrasound is superior for a complete fetal anatomy assessment in the first trimester.
- 3D ultrasound demonstrated lower overall visualization rates but comparable performance for specific structures.
- 3D ultrasound may serve as a supplementary tool in specific clinical scenarios.
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