Related Experiment Video
Updated: Aug 5, 2026
03:47
A Murine Model of Carotid Aneurysm Formation
Published on: September 9, 2025
Novel Morphological Classification of Intracranial Aneurysm Wall Irregularity Associates Specific Features with
Kamil Krystkiewicz1, Aleksander Kowal1, Magdalena Krystkiewicz-Orzechowska2
1Department of Neurosurgery and Neurooncology, Copernicus Memorial Hospital, 93-513 Lodz, Poland.
Neurology International
|July 27, 2026
Summary
Irregular intracranial aneurysm wall patterns are common and linked to larger size and higher rupture risk scores. Further research into these morphological details is recommended for better risk assessment.
Area of Science:
- Neurosurgery
- Radiology
- Vascular Neurology
Background:
- Intracranial aneurysm wall irregularity is a known risk factor.
- The prognostic value of specific irregularity subtypes is not well understood.
Purpose of the Study:
- To investigate the association between intracranial aneurysm wall irregularity subtypes and rupture status.
- To evaluate the prognostic value of different morphological classifications in aneurysm rupture risk.
Main Methods:
- Retrospective cross-sectional study of 180 adult patients with intracranial aneurysms.
- Morphology classified as daughter sac, multilobulated, or complex irregularity.
- Analysis included rupture status, PHASES, ELAPSS, UIATS scores, PCA, and regression models.
Main Results:
- 43.3% of aneurysms exhibited irregularity: daughter sac (25.0%), multilobulated (36.1%), complex (11.1%).
- Ruptured aneurysms showed larger dimensions and higher PHASES/ELAPSS scores.
- Principal Component Analysis identified clusters with distinct rupture risks, linked to daughter sac and multilobulated morphologies.
Conclusions:
- Irregular wall patterns are prevalent in intracranial aneurysms.
- These irregularities correlate with increased aneurysm size and elevated risk scores.
- Refined morphological descriptors may improve aneurysm rupture risk stratification.
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