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Risk Factors for Mortality in Candida auris Bloodstream Infection: A Multicenter Study in South Korea, 2018-2025
Min Han1, Jin Young Ahn1, Jae Eun Seong2
1Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Journal of Fungi (Basel, Switzerland)
|July 27, 2026
Summary
Candida auris bloodstream infections (BSI) are a serious threat, causing significant mortality. Older age and higher organ failure scores increase 30-day mortality risk for Candida auris BSI.
Area of Science:
- Infectious Diseases
- Critical Care Medicine
- Public Health
Background:
- Candida auris is a multidrug-resistant fungus and an urgent threat pathogen.
- It spreads clonally in healthcare settings, posing a significant public health challenge.
- Identifying mortality risk factors for C. auris bloodstream infection (BSI) is crucial.
Purpose of the Study:
- To identify mortality risk factors in patients with C. auris bloodstream infection (BSI) in South Korea.
- To analyze the association between patient characteristics, management, and outcomes.
- To inform clinical management strategies for C. auris BSI.
Main Methods:
- Retrospective cohort study across three tertiary care centers.
- Inclusion of 50 adult patients with first-episode C. auris BSI.
- Analysis of 30-day and 90-day mortality, risk factors, and microbiological clearance.
Main Results:
- 30-day mortality was 24%, and 90-day mortality was 46%.
- Older age and higher Sequential Organ Failure Assessment (SOFA) score were independent risk factors for 30-day mortality.
- Microbiologic clearance within 30 or 90 days was protective against mortality.
Conclusions:
- C. auris BSI is associated with substantial short-term mortality.
- Risk stratification and achieving microbiologic clearance are key management goals.
- Further research into effective treatment strategies is warranted.
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