Related Experiment Video
Updated: Aug 5, 2026
07:42
Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients
Published on: December 16, 2022
Five-Year Changes in Physical and Cognitive Function in Individuals with Chronic Stroke: An Ambispective Cohort Study
Yanisa Sinthunyathum1, Nantaporn Jitpimolmard1, Jittima Saengsuwan1
1Department of Rehabilitation Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Medical Sciences (Basel, Switzerland)
|July 27, 2026
Summary
Physical function significantly declined over five years in chronic stroke survivors, emphasizing the need for ongoing care. Cognitive function remained stable, but factors like stroke severity and nutrition influenced outcomes.
Area of Science:
- Neurology
- Rehabilitation Medicine
- Gerontology
Background:
- Chronic stroke impacts long-term physical and cognitive function.
- Understanding longitudinal changes is crucial for effective patient management.
- Previous cross-sectional data provides a baseline for this cohort study.
Purpose of the Study:
- To evaluate five-year changes in physical and cognitive function post-stroke.
- To identify factors associated with long-term physical and cognitive outcomes.
- To inform rehabilitation strategies and long-term care planning for stroke survivors.
Main Methods:
- Ambispective cohort study design.
- Inclusion of individuals from a prior cross-sectional study.
- Assessment of physical function (6MWT, 10MWT) and cognitive function (MMSE) at baseline and five-year follow-up.
Main Results:
- Significant 22% decline in six-minute walk distance (6MWT) over five years.
- No significant changes observed in gait speed or global cognitive function (MMSE).
- Baseline stroke severity (NIHSS), nutritional status (MNA-SF), and initial functional/cognitive scores were associated with outcomes.
Conclusions:
- Chronic stroke leads to progressive physical function decline over five years.
- Global cognitive function appears stable, but domain-specific changes are possible.
- Early stroke severity, nutritional status, and baseline performance predict long-term recovery trajectories.
Related Concept Videos
01:30Cognitive Development During Adulthood
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
01:15Ischemic Stroke l: Introduction
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.