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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
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Imaging-Based Risk Stratification for Sudden Cardiac Death in Hypertrophic Cardiomyopathy: Current Evidence and

Èlia Rifé-Pardo1, Sara Sóñora-López1, Guillem Casas1,2,3

  • 1Department of Cardiology, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.

Medical Sciences (Basel, Switzerland)
|July 27, 2026
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) risk stratification for sudden cardiac death (SCD) is challenging. Cardiac imaging offers advanced predictors, improving risk assessment by linking biomarkers to disease mechanisms.

Area of Science:

  • Cardiology
  • Inherited Cardiovascular Diseases
  • Medical Imaging

Background:

  • Hypertrophic cardiomyopathy (HCM) is a common inherited myocardial disorder.
  • It is a leading cause of sudden cardiac death (SCD) across all age groups.
  • Current risk stratification algorithms inadequately capture the arrhythmic substrate in HCM.

Purpose of the Study:

  • To synthesize imaging-derived predictors of SCD in HCM.
  • To review established and advanced cardiac imaging techniques for risk stratification.
  • To highlight future directions for precision SCD risk assessment in HCM.

Main Methods:

  • Review of established echocardiographic markers (e.g., wall thickness, ejection fraction, outflow tract obstruction).
  • Examination of advanced cardiovascular magnetic resonance (CMR) parameters (e.g., late gadolinium enhancement, apical aneurysm).
  • Discussion of emerging techniques like extracellular volume, quantitative mapping, and strain abnormalities.

Main Results:

  • Cardiac imaging provides detailed structural, functional, and tissue data for SCD prediction.
  • Established echocardiographic and advanced CMR parameters are key predictors.
  • Emerging imaging biomarkers show promise for refining risk models.

Conclusions:

  • Cardiac imaging is pivotal for improving SCD risk stratification in HCM.
  • Integrating imaging biomarkers with pathophysiological mechanisms enhances precision.
  • Further research is needed to optimize contemporary risk stratification models.

Keywords:
hypertrophic cardiomyopathyimaginglate gadolinium enhancementstrainsudden cardiac death

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