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Updated: Aug 5, 2026
07:15
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Published on: July 31, 2019
Short-Chain Fatty Acids: Bridging Gut Microbiota and Systemic Aging-Mechanisms, Interventions, and Current Challenges
Pengpeng Xie1, Yaoye Pei2, Luyun Xu1
1School of Life Sciences, Soochow University, Suzhou 215123, China.
Metabolites
|July 27, 2026
Summary
Short-chain fatty acids (SCFAs) are vital for anti-aging, connecting gut health to systemic processes. Understanding their molecular mechanisms can lead to personalized interventions for age-related decline.
Area of Science:
- Gerontology
- Metabolomics
- Molecular Biology
Background:
- Aging is a systemic process impacting multiple organs.
- Short-chain fatty acids (SCFAs) link gut health and aging, with changing levels and functions during aging.
- Current knowledge on SCFA downstream molecular mechanisms and interventions is limited.
Purpose of the Study:
- To clarify the relationship between SCFAs and aging from a systemic viewpoint.
- To analyze SCFA regulatory mechanisms via key signaling pathways.
- To summarize SCFA therapeutic potential and intervention strategies for aging-related diseases.
Main Methods:
- Systemic analysis of SCFA-aging interactions.
- Investigation of SCFA roles in tissue barrier protection, metabolic disorders, and immune regulation.
- Review of current and potential intervention strategies.
Main Results:
- SCFAs mediate organ-to-organ interactions that influence aging.
- SCFAs play roles in maintaining tissue barriers, improving metabolic health, and regulating immunity.
- Existing interventions for SCFA-related aging are not precise.
Conclusions:
- SCFAs are critical regulators of the aging process.
- Further research using advanced techniques like single-cell sequencing is needed to elucidate precise molecular mechanisms.
- Development of personalized, metabolite-mediated anti-aging interventions is a future goal.
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