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Uric Acid Extremes and Lipid Dysregulation: Evidence from a Large Population-Based Study
Yazeed Alshuweishi1, Ahmed M Basudan1, Zeina S Alkudmani1
1Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 12372, Saudi Arabia.
Metabolites
|July 27, 2026
Summary
High uric acid (hyperuricemia) is linked to unhealthy lipid profiles, while low uric acid (hypouricemia) is associated with better lipid metabolism. This study clarifies the relationship between uric acid levels and lipid abnormalities in adults.
Area of Science:
- Metabolic Health
- Lipidomics
- Clinical Biochemistry
Background:
- Uric acid (UA) has a dual role as an antioxidant or pro-oxidant, concentration-dependent.
- The association between uric acid levels and lipid metabolism across its spectrum is not fully understood.
Purpose of the Study:
- To investigate lipid abnormalities across the full spectrum of uric acid levels in a large adult population.
- To explore the relationship between serum uric acid concentrations and various lipid parameters.
Main Methods:
- Analysis of 13,223 adults classified into hypouricemic, normouricemic, and hyperuricemic groups.
- Evaluation of lipid profiles, prevalence, associations, risk estimates, and diagnostic accuracy using statistical analyses.
Main Results:
- Hyperuricemia (17.26%) showed higher LDL, TC, TG, and lower HDL (p < 0.0001).
- Hypouricemia (2%) exhibited elevated HDL and lower LDL, TC, TG.
- Lipid abnormalities were most frequent in hyperuricemia; hypouricemia showed reduced odds of abnormalities.
Conclusions:
- Extreme uric acid levels indicate distinct metabolic states.
- Hyperuricemia is associated with an adverse lipid profile.
- Hypouricemia correlates with a more favorable lipid profile, underscoring the link between UA and lipid metabolism.
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