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Fibrinolysis in grafted arteries and veins

B Risberg

    Thrombosis and Haemostasis
    |February 15, 1979
    PubMed

    Insights

    Vascular grafts show altered fibrinolytic activity. Arterial grafts in veins increase activity, while venous grafts in arteries decrease it, impacting clot breakdown.

    Area of Science:

    • Vascular biology
    • Hemostasis
    • Biomaterials science

    Background:

    • Autologous grafts are used in vascular surgery.
    • Fibrinolytic activity is crucial for graft patency.
    • Understanding graft-specific responses is important.

    Purpose of the Study:

    • To investigate fibrinolytic activity in autologous artery and vein grafts.
    • To compare fibrinolytic changes in arterial segments within venous environments and vice versa.
    • To assess the impact of thrombosis on graft fibrinolytic potential.

    Main Methods:

    • Cats were used as a model.
    • Autologous aortic and caval vein segments were surgically interposed.
    • Fibrinolytic activity was measured over a 4-month period.
    • Sham surgeries were performed as controls.

    Main Results:

    • Interposing aortic segments into the caval vein increased vessel wall fibrinolytic activity.
    • Interposing caval vein segments into the aorta reduced fibrinolytic activity.
    • Thrombosed graft segments exhibited decreased fibrinolytic activity.
    • Sham-operated animals showed no significant changes.

    Conclusions:

    • The surrounding vascular environment significantly influences graft fibrinolytic activity.
    • Arterial and venous grafts respond differently when placed in new environments.
    • Reduced fibrinolytic activity in thrombosed segments suggests a role in graft failure.

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