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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
Challenges and Future Perspectives for Vaccines Targeting the Tumor Microenvironment
Devin B Lowe1, Neda Feizi2, Walter J Storkus2,3,4
1Department of Immunotherapeutics and Biotechnology, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, TX 79601, USA.
Immune checkpoint inhibitors (ICI) show promise in cancer treatment but face resistance. This study explores novel strategies to overcome resistance and improve immunotherapy effectiveness for solid tumors.
Area of Science:
- Oncology
- Immunology
- Cancer Research
Background:
- Immune checkpoint inhibitors (ICI) are standard cancer care.
- Limited patient response to ICI is due to resistance mechanisms.
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