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Tuberculosis-Related Hospitalization According to Comorbidity Burden: A Retrospective Single-Center Cohort Study
Oh Beom Kwon1, Yeonjeong Heo1, Da Hye Moon1
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kangwon National University Hospital, Chuncheon 24289, Republic of Korea.
Tropical Medicine and Infectious Disease
|July 27, 2026
Summary
Tuberculosis (TB) hospitalization risk is linked to higher comorbidity burden and elevated serum creatinine. Identifying these factors can help predict which TB patients may require hospitalization.
Area of Science:
- Infectious Diseases
- Clinical Medicine
- Public Health
Background:
- Tuberculosis (TB) presents a significant global health challenge with substantial healthcare costs.
- While TB mortality and treatment outcomes are well-studied, factors influencing TB-related hospitalizations require further investigation.
Purpose of the Study:
- To identify clinical factors associated with TB-related hospitalization in patients diagnosed with TB.
- To evaluate the risk of hospitalization based on patient comorbidities and clinical markers.
Main Methods:
- Retrospective cohort study including 81 patients diagnosed with TB.
- Kaplan-Meier analysis for hospitalization-free probability and Cox proportional hazards regression for risk factor identification.
- Analysis of clinical factors including Charlson Comorbidity Index (CCI) and serum creatinine levels.
Main Results:
- The hospitalization group had a significantly higher Charlson Comorbidity Index (CCI) compared to the outpatient group (p=0.038).
- Patients with CCI ≥ 5 had a significantly lower hospitalization-free probability (log-rank p=0.013).
- Serum creatinine (HR 1.599) and CCI (HR 1.221) were significantly associated with TB-related hospitalization risk in multivariable analysis.
Conclusions:
- A higher comorbidity burden, indicated by CCI, is a significant predictor of TB-related hospitalization.
- Elevated serum creatinine levels also independently predict hospitalization risk in TB patients.
- These findings suggest that assessing comorbidity burden and renal function can aid in identifying TB patients at higher risk for hospitalization.
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