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Related Experiment Videos

Shear stress-induced changes in platelet reactivity.

S K Yu, J G Latour, B Marchandise

    Thrombosis and Haemostasis
    |February 15, 1979
    PubMed
    Summary

    Physiologic shear stress enhances platelet aggregation and reactivity. Platelets from coronary artery disease patients showed increased procoagulant activity under flow conditions, suggesting a role in atherosclerosis.

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    Medical physics·2017

    Area of Science:

    • Biomedical Engineering
    • Hematology
    • Cardiovascular Research

    Background:

    • Platelet function is crucial in hemostasis and thrombosis.
    • Altered platelet activity is implicated in cardiovascular diseases like atherosclerosis.
    • Understanding the impact of shear stress on platelets is vital for cardiovascular research.

    Purpose of the Study:

    • To investigate the effects of physiologic shear stress on platelet function.
    • To compare platelet responses in healthy volunteers and patients with coronary artery disease (CAD).
    • To assess the impact of laminar oscillatory flow on platelet aggregation, release reaction, and procoagulant activity.

    Main Methods:

    • Washed platelet suspensions from 15 healthy volunteers and 15 CAD patients were subjected to laminar oscillatory flow (26.2 dynes/cm2, 72 cycles/min) for 20 minutes at 37°C.
    • Platelet aggregation (thrombin, collagen), release reaction ((14C) serotonin), and procoagulant activity were measured.
    • Paired samples were kept at rest for control comparison.

    Main Results:

    • Oscillatory flow significantly enhanced platelet aggregation in response to thrombin and collagen.
    • Platelets from CAD patients exhibited increased procoagulant activity when exposed to shear stress.
    • No significant changes were observed in the rate or speed of the platelet release reaction.

    Conclusions:

    • Exposure to physiologic shear stress in an oscillatory flow system increases platelet reactivity.
    • Enhanced platelet reactivity and procoagulant activity may contribute to the pathophysiology of atherosclerosis.
    • These findings highlight the potential role of shear stress in platelet and coagulation alterations observed in atherosclerotic patients.

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