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Radiographic Analysis of Lower Limb Alignment in Patients with Knee Osteoarthritis
Ozden Bedre Duygu1, Figen Govsa2, Anil Murat Ozturk3
1Department of Anatomy, Faculty of Medicine, Izmir Bakircay University, 35660 Izmir, Turkey.
Tomography (Ann Arbor, Mich.)
|July 27, 2026
Summary
This study reveals that knee osteoarthritis (OA) progression is linked to significant changes in lower-extremity alignment, particularly in the hip-knee-ankle axis. Advanced OA stages show increased angular measurements, suggesting biomechanical alterations.
Area of Science:
- Orthopedics
- Radiology
- Biomechanical Engineering
Background:
- Knee osteoarthritis (OA) is a widespread musculoskeletal condition.
- Understanding lower-extremity alignment is crucial for OA management.
Purpose of the Study:
- To evaluate hip-knee-ankle anatomical alignment in knee OA patients across different disease stages.
- To identify correlations between alignment parameters and OA severity.
Main Methods:
- Radiological images of 200 knee OA patients were analyzed.
- Key parameters including femoral and tibial lengths, hip center length, femoral offset, and various angular measurements were quantified using ImageJ software.
- Data were stratified by sex, age, and Kellgren-Lawrence OA stage.
Main Results:
- Significant differences in linear and angular parameters were observed between sexes and age groups.
- Higher Q angle, hip-knee-ankle angle, and other angular measurements were noted in females and older individuals (62-75 years).
- Advanced OA (Stage 4) showed significant increases in Q angle, hip-knee-ankle angle, and related angular parameters.
Conclusions:
- Comprehensive assessment of lower-extremity alignment offers valuable insights into biomechanical changes during knee OA progression.
- These findings can aid in personalized clinical follow-up and treatment strategies for knee OA.
