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Hispanic versus non-Hispanic patients with Central Serous Chorioretinopathy: MICRoN report 18
Shreyaa Rohindra Lall1, Niroj Kumar Sahoo1, Nasiq Hasan1
1Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh.
Purpose:
To compare baseline characteristics and clinical course between Hispanic and non-Hispanic patients with Central Serous Chorioretinopathy (CSC).
Methods:
This retrospective, multicentre study from the Macula Society CSC Research Network (MICRoN) included Hispanic and non-Hispanic patients with CSC. Demographic characteristics and multimodal imaging variables were compared between groups. Regression analyses identified factors associated with visual outcomes, structural changes, and disease recurrence/persistence.
Results:
A total of 480 patients were included (130 Hispanic, 350 non-Hispanic). Non-Hispanic patients were significantly older at presentation (48.8±11.1 vs 45.3±11.6 years, p=0.003) and had better baseline best recorded visual acuity (BRVA; 20/25 vs 20/40, p<0.001). A significantly higher percentage of Hispanic patients presented with complex CSC (73.8% vs 28.3%, p<0.001), multifocal RPE alterations (58.5% vs 9.7%, p<0.001), and greater neurosensory detachment height (NSD; 193 [IQR 100-301] vs 113 [IQR 66-193] microns, p<0.001). Conversely, non-Hispanic patients demonstrated larger areas of RPE alteration (1.5 [IQR 1-3] vs 1 [IQR 0.25-1.5] disc areas, p<0.001). At last follow-up, both groups showed significant improvement in BRVA (Hispanics: 20/40 to 20/25, p<0.001; non-Hispanics: 20/25 to 20/20, p<0.001), with no significant difference in rates of recurrence (40% vs 35.7%, p=0.08) or persistence (11.5% vs 13.1%, p=0.08).
Conclusion:
In our cohort, Hispanic patients more commonly presented with complex CSC, multifocal RPE alterations, and greater NSD height, while non-Hispanic patients were older with better baseline vision and larger areas of RPE alteration. Despite these differences, visual outcomes improved meaningfully in both groups, with comparable rates of recurrence and persistence.
Insights
Hispanic and non-Hispanic patients with Central Serous Chorioretinopathy (CSC) present differently but achieve similar visual outcomes and disease persistence rates. This study highlights ethnic variations in CSC presentation and management effectiveness.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Public Health
Background:
- Central Serous Chorioretinopathy (CSC) is a condition affecting vision.
- Understanding ethnic differences in CSC presentation and outcomes is crucial for equitable healthcare.
- Previous research has not fully elucidated the specific characteristics of CSC in Hispanic populations compared to others.
Purpose of the Study:
- To compare baseline characteristics and clinical course between Hispanic and non-Hispanic patients diagnosed with Central Serous Chorioretinopathy (CSC).
- To identify factors influencing visual outcomes, structural changes, and disease persistence in different ethnic groups with CSC.
Main Methods:
- A retrospective, multicentre study involving 480 patients with CSC (130 Hispanic, 350 non-Hispanic) from the Macula Society CSC Research Network (MICRoN).
- Comparison of demographic data and multimodal imaging variables between Hispanic and non-Hispanic cohorts.
- Utilized regression analyses to determine predictors of visual acuity, structural alterations, and disease recurrence/persistence.
Main Results:
- Hispanic patients presented with more complex CSC, multifocal RPE alterations, and greater neurosensory detachment (NSD) height compared to non-Hispanic patients.
- Non-Hispanic patients were older at presentation, had better baseline visual acuity, and larger areas of RPE alteration.
- Both groups demonstrated significant visual acuity improvement, with comparable rates of CSC recurrence (40% vs 35.7%) and persistence (11.5% vs 13.1%) at last follow-up.
Conclusions:
- Significant ethnic differences exist in the baseline presentation of Central Serous Chorioretinopathy (CSC), with Hispanic patients exhibiting more severe structural changes.
- Despite initial presentation disparities, both Hispanic and non-Hispanic patients experienced meaningful visual recovery.
- The study indicates comparable long-term disease course, including recurrence and persistence rates, between the two ethnic groups, suggesting similar treatment efficacy.
