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Published on: January 21, 2020
Association between Albumin-to-Globulin Ratio and Periodontitis: A Cross-Sectional and Mendelian Randomisation
Oral Health & Preventive Dentistry
|July 27, 2026
Summary
Higher albumin-to-globulin ratio (AGR) is linked to reduced periodontitis prevalence, especially in older adults. However, genetic analysis did not confirm this association, warranting further investigation.
Area of Science:
- Oral health research
- Nutritional biomarkers
- Inflammation markers
Background:
- Periodontitis is associated with systemic inflammation and nutritional status.
- The albumin-to-globulin ratio (AGR) is a potential indicator of inflammation and nutrition.
- The relationship between AGR and periodontitis requires further clarification.
Purpose of the Study:
- To investigate the association between AGR and periodontitis.
- To utilize National Health and Nutrition Examination Survey (NHANES) data and Mendelian randomization (MR).
Main Methods:
- Cross-sectional analysis of 10,094 NHANES participants (2009-2014).
- Weighted multivariable logistic regression, restricted cubic splines (RCS), and subgroup analyses were performed.
- MR analysis used genetic data for AGR and periodontitis.
Main Results:
- Elevated AGR was associated with lower odds of periodontitis (OR = 0.52).
- A nonlinear, L-shaped association was observed between AGR and periodontitis.
- The association was stronger in participants aged 60 years; MR analysis found no genetic correlation.
Conclusions:
- Higher AGR correlates with lower periodontitis prevalence, particularly in older adults.
- Genetic evidence supporting the AGR-periodontitis link is lacking.
- Prospective studies are necessary to elucidate this relationship.