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Integrated Genomic, Transcriptomic and Metabolomic Analyses Identify Key Genetic Determinants and Regulatory Networks
Zhang Jiahua1, Zhang Min1, Huang Chungui1
1Jiangsu Fisheries Technology Extension Center, Nanjing, 210036, China.
Marine Biotechnology (New York, N.Y.)
|July 27, 2026
Summary
The NY strain of Macrobrachium rosenbergii exhibits enhanced salinity tolerance through genetic, transcriptional, and metabolic adaptations. This study reveals key molecular mechanisms for improved salt adaptability in shrimp.
Area of Science:
- Aquaculture
- Genomics
- Molecular Biology
Background:
- Salinity stress limits Macrobrachium rosenbergii cultivation.
- A salt-tolerant NY strain was developed, outperforming commercial strains (SH, PT).
Purpose of the Study:
- To elucidate the molecular basis of salinity tolerance in the NY strain.
- To identify genetic and metabolic adaptations contributing to salt tolerance.
Main Methods:
- Whole-genome resequencing, transcriptome, and untargeted metabolomic analyses.
- Population genetic analyses (ADMIXTURE, PCA, Fst scanning).
- Differential gene expression and metabolite accumulation analysis.
Main Results:
- Genetic differentiation observed between NY, SH, and PT strains.
- Differentially expressed genes (DEGs) involved in metabolism, autophagy, and homeostasis.
- Differentially accumulated metabolites (DAMs) enriched in carbohydrate metabolism and transport pathways.
- Coordinated variations in genes and metabolites related to osmotic adjustment and ion transport.
Conclusions:
- The NY strain's salinity tolerance results from integrated genetic, transcriptional, and metabolic remodeling.
- Mechanisms include maintaining ion homeostasis, osmotic balance, and energy supply.
- Provides resources for M. rosenbergii breeding and salinity adaptation research.
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