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Rotating the Intraocular Lens to Prevent Posterior Capsular Opacification in Cataract Surgeries
Published on: July 7, 2023
Risk factors for late intraocular lens dislocation: a systematic review and meta-analysis
Natalia S Anisimova1,2, Maxim V Ivanov2, Lisa B Arbisser3
1Russian University of Medicine, Moscow, Russia (Anisimova N.S.).
Journal of Cataract and Refractive Surgery
|July 27, 2026
Summary
Late intraocular lens (IOL) dislocation after cataract surgery is strongly linked to zonular weakness, trauma, uveitis, and pseudoexfoliation syndrome. These factors damage the capsular-zonular complex, increasing the risk of this complication.
Area of Science:
- Ophthalmology
- Surgical Complications
- Biomaterials Science
Background:
- Late intraocular lens (IOL) dislocation is a rare but significant long-term complication following cataract surgery.
- Previous studies have identified potential risk factors, but their relative contributions remain unquantified.
Purpose of the Study:
- To systematically review and quantify the associations between various risk factors and late IOL dislocation.
- To provide a comprehensive analysis of predisposing conditions for IOL dislocation post-phacoemulsification.
Main Methods:
- A systematic review and meta-analysis adhering to PRISMA guidelines.
- Inclusion of comparative observational studies (meta-analysis) and non-comparative studies (descriptive synthesis) published between 2000-2025.
- Utilized random-effects models to calculate odds ratios (OR) and 95% confidence intervals (CI) for risk factors.
Main Results:
- Strongest associations with late IOL dislocation were found for zonular weakness (OR 8.04), ocular trauma (OR 5.98), uveitis (OR 5.73), and pseudoexfoliation syndrome (OR 5.72).
- Moderate associations were observed for myopia (OR 3.32) and glaucoma (OR 2.60).
- Previous vitrectomy and male sex did not show statistically significant associations.
Conclusions:
- Late IOL dislocation is primarily associated with structural damage or inflammation affecting the capsular-zonular complex.
- While certain factors are prevalent, their independent pathogenetic significance requires careful consideration.
