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Dietitian-led intervention to manage constipation in Parkinson's disease: Study protocol for a parallel-group
Juliana Heitich Brendler1, Khadija Younes da Silva2, Valesca Dall'Alba2,3
1Graduate Program in Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Plos One
|July 27, 2026
Summary
This study investigated if dietitian-led nutritional counseling improves constipation in Parkinson's Disease (PD) patients more than usual care. Results will guide dietary strategies for managing PD constipation.
Area of Science:
- Neurology
- Gastroenterology
- Nutritional Science
Background:
- Constipation is a common non-motor symptom in Parkinson's Disease (PD).
- Current management includes lifestyle advice or laxatives, but dietary interventions are complex in PD.
- This study explores dietitian-led nutritional counseling as a non-pharmacological approach for PD constipation.
Purpose of the Study:
- To determine if nutritional counseling by a dietitian is superior to usual care in alleviating constipation symptoms in PD patients.
- To assess the impact of nutritional counseling on bowel movement frequency and constipation severity.
Main Methods:
- A 90-day randomized controlled superiority trial involving 54 PD outpatients with functional constipation.
- Participants were randomized to usual care or dietitian-led nutritional counseling (healthy eating, fiber/fluid intake, levodopa interactions).
- Outcomes included changes in bowel movement frequency, Constipation Scoring System (CSS) scores, gut microbiota, and body composition.
Main Results:
- Primary outcome: change in weekly bowel movement frequency from baseline to day 90.
- Secondary outcomes: changes in CSS, gut microbiota composition, diet quality, and body composition.
- Intervention group received individualized diet plans and regular follow-ups.
Conclusions:
- Nutritional counseling may offer a viable non-pharmacological strategy for managing constipation in Parkinson's Disease.
- Further analysis of secondary outcomes will provide comprehensive insights into the intervention's effects.
- This trial contributes to understanding personalized dietary management in PD non-motor symptoms.
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