Triterpenoids and Lignans From Schisandra henryi subsp. yunnanensis A. C. Smith

Three new triterpenoids, henridilactones P-R (1-3) and two new dibenzocyclooctadiene lignans, henrilignans A and B (11 and 12), alongside twelve known analogues (4-10 and 13-17) were isolated from the stems and leaves of Schisandra henryi subsp. yunnanensis. The structures and absolute configurations of new compounds were elucidated by comprehensive 1D and 2D NMR, HRESIMS, electronic circular dichroism analyses, and theoretical calculations. In bioactivity evaluation, the isolated triterpenoids (1-10) exhibited moderate neurite outgrowth in differentiated PC12 cells at 10 µM (differentiation rates 10.09%-12.96%; positive control 50 ng/mL NGF, 19.71%). Furthermore, henridilactone P (1) exhibited a binding affinity with an equilibrium dissociation constant (K_D) of 3.286 × 10^{- 4} M (reference compound PF-06446846, K_D = 8.008 × 10^{- 5} M).