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Updated: Aug 5, 2026

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AI-derived-intrinsically disordered proteins from antarctic nematode stabilize human cells under freezing stress

Haoyu Wang1, Tianyu Zheng1, Chang Liu1

  • 1Henan Key Laboratory for Helicobacter pylori and Digestive Tract Microecology, The Fifth Affiliated Hospital of Zhengzhou University, Institute of Rehabilitation Medicine, Henan Academy of Innovations in Medical Science, Tianjian Laboratory of Advanced Biomedical Sciences, Zhengzhou University, Zhengzhou, 450000, Henan, China; Department of Gastroenterology, Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

Biomaterials Advances
|July 27, 2026
PubMed
Summary

Researchers explored Antarctic nematode proteins to find new cryoprotectants. They discovered that a mixture of Intrinsically Disordered Proteins (IDPs) effectively protects cells from cold damage, offering potential for cryobiology and biobanking applications.

Keywords:
Antarctic NematodesCross-Species ConservationCryopreservationIntrinsically Disordered ProteinsStress Response

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