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14:05
Morphological and Compositional Analysis of Neutrophil Extracellular Traps Induced by Microbial and Chemical Stimuli
Published on: November 4, 2022
Neutrophilic Dermatoses
Emiley Vrooman1, Jane M Grant-Kels2
1University of Connecticut School of Medicine, Farmington, CT, USA.
Clinics in Dermatology
|July 27, 2026
Summary
Neutrophilic dermatoses are rare inflammatory skin disorders linked to underlying cancers. This review covers their clinical and histopathologic features, treatment, and potential as early malignancy indicators.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Neutrophilic dermatoses are rare inflammatory conditions characterized by sterile neutrophilic infiltrates.
- These disorders can be cutaneous manifestations of underlying systemic illnesses, particularly malignancies.
- Clinical presentations are diverse, including papules, plaques, nodules, and ulcerations.
Purpose of the Study:
- To review the clinical and histopathologic features of neutrophilic dermatoses associated with malignancy.
- To discuss current treatment options for these conditions.
- To highlight their role as potential early indicators of underlying cancer.
Main Methods:
- Literature review of neutrophilic dermatoses.
- Analysis of clinical and histopathologic findings.
- Discussion of treatment strategies and paraneoplastic associations.
Main Results:
- Several neutrophilic dermatoses, including Sweet syndrome, pyoderma gangrenosum, and Behçet's disease, are associated with malignancy.
- Cutaneous vasculitis and eosinophilic paraneoplastic dermatoses are also discussed as potential malignancy markers.
- These dermatologic conditions can precede the diagnosis of an underlying cancer.
Conclusions:
- Neutrophilic dermatoses represent a significant group of disorders that warrant investigation for underlying malignancy.
- Early recognition of these skin conditions can lead to timely cancer diagnosis and management.
- Further research is needed to elucidate the mechanisms linking these dermatoses to cancer.
Keywords:
Schnitzler Syndrome neutrophilic urticarial dermatosis, underlying malignancy, paraneoplasticneutrophils, neutrophilic dermatoses, Sweet syndrome, pyoderma gangrenosum, neutrophilic eccrine hidradenitis, subcorneal pustular dermatosis, Sneddon-Wilkinson disease, vasculitis, leukocytoclastic vasculitis, erythema elevatum diutiunum, Bazex syndrome, VEXAS syndromeMore Related Videos
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