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Updated: Aug 5, 2026
06:46
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
Invasive Front and Peritumoral Prognostic Factors in Colorectal Cancer: Current Perspectives and Future
Sameer Shivji1, Rish K Pai2, Richard Kirsch2
1Department of Laboratory Medicine, William Osler Health System, 2100 Bovaird Dr E, Brampton, ON L6R 3J7, Canada.
Surgical Pathology Clinics
|July 27, 2026
Summary
Prognostic biomarkers in colorectal cancer
Area of Science:
- Oncology
- Pathology
Background:
- The invasive front and peritumoral region of colorectal cancers contain prognostic biomarkers.
- These biomarkers offer superior prediction of oncologic outcomes compared to TNM staging alone.
Purpose of the Study:
- To review established and emerging prognostic factors in the invasive front/peritumoral region of colorectal cancers.
- To discuss recent developments, clinical considerations, diagnostic challenges, and automated assessment for these factors.
Main Methods:
- Literature review of established and emerging prognostic factors.
- Analysis of recent developments and practical considerations.
- Discussion of diagnostic challenges and automated assessment potential.
Main Results:
- Invasive front and peritumoral biomarkers provide precise oncologic outcome prediction.
- Established and emerging factors offer significant prognostic value beyond TNM staging.
Conclusions:
- Prognostic factors in the invasive front/peritumoral region are crucial for colorectal cancer management.
- Automated assessment may facilitate the integration of these biomarkers into clinical practice.
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