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Invasive Front and Peritumoral Prognostic Factors in Colorectal Cancer: Current Perspectives and Future
Sameer Shivji1, Rish K Pai2, Richard Kirsch2
1Department of Laboratory Medicine, William Osler Health System, 2100 Bovaird Dr E, Brampton, ON L6R 3J7, Canada.
Abstract:
The invasive front and peritumoral region of colorectal cancers are replete with powerful prognostic biomarkers that can predict oncologic outcomes with far greater precision than achievable by tumor, node, metastasis (TNM) stage alone. This article considers both established and emerging invasive front/peritumoral prognostic factors with an emphasis on recent developments, practical considerations, diagnostic challenges, and the potential role of automated assessment in the integration of emerging prognostic factors into future clinical practice.
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