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Optimizing ECT in a complex neuroanatomical context: A case-based approach combining clinical outcome and electric
Julie Gosez1, Tom Le Tutour2, Anish Sarkar3
1Pierre-Deniker Clinical Research Unit, Henri Laborit Hospital Centre, Poitiers, France; Pprime Institut, UPR 3346, University of Poitiers, Poitiers, France; Ansys France, Villeurbanne, France.
L'Encephale
|July 27, 2026
Summary
Switching to right unilateral stimulation in electroconvulsive therapy (ECT) successfully re-induced seizures in a patient with treatment-resistant schizophrenia and a meningioma. Computational modeling supported this approach for optimizing ECT parameters.
Area of Science:
- Neuroscience
- Psychiatry
- Medical Imaging
Background:
- Electroconvulsive therapy (ECT) is effective for treatment-resistant schizophrenia, but seizure induction can be challenging.
- High seizure thresholds and anatomical variations, like meningiomas, can complicate ECT.
- Case presentation of a patient with chronic treatment-resistant schizophrenia and a meningioma experiencing ECT resistance.
