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Associations between non-high-density lipoprotein cholesterol levels and renal pathological changes in a population
Eri Ataka1, Yuta Matsukuma1, Kenji Ueki1
1Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University (Ataka, Matsukuma, Ueki, Tsuchimoto, and Kitazono), Fukuoka, Japan.
Journal of Clinical Lipidology
|July 27, 2026
Summary
High non-high-density lipoprotein cholesterol (nHDL-C) levels may indicate kidney damage in healthy individuals. This study found associations between elevated nHDL-C and renal pathological changes, suggesting nHDL-C as a potential biomarker for kidney injury.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Biochemistry
Background:
- Dyslipidemia is a key risk factor for atherosclerotic disease.
- Non-high-density lipoprotein cholesterol (nHDL-C) is increasingly linked to cardiovascular disease and chronic kidney disease (CKD).
- Limited research exists on the relationship between nHDL-C and renal pathology.
Purpose of the Study:
- To investigate the association between nHDL-C levels and renal pathological changes.
- To examine these associations in living kidney donors with normal kidney function.
Main Methods:
- Cross-sectional study of 345 living kidney donors.
- Analysis of time-zero biopsy specimens.
- Evaluation of serum nHDL-C levels against renal pathology (arteriolar hyalinization, luminal stenosis, glomerulosclerosis, glomerular hypertrophy).
- Net reclassification improvement (NRI) analysis comparing nHDL-C and LDL-C predictive performance.
Main Results:
- High nHDL-C (≥170 mg/dL) was significantly associated with severe luminal stenosis (OR: 3.62).
- Elevated nHDL-C levels correlated with glomerular hypertrophy (OR per 10 mg/dL increase: 1.19).
- nHDL-C demonstrated superior predictive performance for severe luminal stenosis compared to LDL-C in NRI analysis.
Conclusions:
- Elevated nHDL-C levels show a potential association with renal pathological injury.
- nHDL-C may serve as a valuable biomarker for subclinical kidney damage in individuals without diagnosed CKD.
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