Related Experiment Video For Fine-needle biopsy
Updated: Aug 5, 2026
Use of Electromagnetic Navigational Transthoracic Needle Aspiration (E-TTNA) for Sampling of Lung Nodules
Published on: May 23, 2015
Sampling performance of EUS-Guided fine-needle biopsy in pancreatic neuroendocrine tumors: A systematic review and
Juan Manuel Millan-Alanis1, Luis Andrés González-Torres1, Joel Omar Jáquez-Quintana1
1Gastroenterology Department, University Hospital "Dr. Jose E. González", Universidad Autónoma de Nuevo León, Mexico.
Background/Objectives:
Pancreatic neuroendocrine tumors (PNETs) account for a growing proportion of pancreatic lesions. Adequate tissue acquisition is essential for accurate diagnosis, tumor grading, and treatment planning. Fine-needle biopsy (FNB) has emerged as a promising alternative to fine-needle aspiration (FNA) for obtaining diagnostic samples.
Methods:
We conducted a systematic review and meta-analysis of clinical trials and cohort studies evaluating the sampling performance of FNB in patients with suspected PNETs. A comprehensive search was performed across multiple databases. Two independent reviewers screened studies for inclusion, extracted data, and assessed risk of bias. A meta-analysis of event proportions was conducted to evaluate the sampling performance of FNB overall, in comparison to FNA, and across different FNB needle types. Certainty of evidence was evaluated using the GRADE approach.
Results:
Twelve studies involving 846 patients met inclusion criteria. FNB achieved adequate tissue sampling in 89% of cases and enabled Ki-67 proliferative index assessment in 96%. Diagnostic concordance with surgical specimens was 82%, with 80% tumor grade agreement among concordant cases. Among FNB devices, the Sharkcore needle demonstrated the highest performance. Compared to FNA, FNB more reliably yielded adequate samples for histological and Ki-67 evaluation. Risk of bias was moderate to high across several domains, and the certainty of evidence ranged from moderate to very low.
Conclusions:
FNB appears to provide favorable procedural and pathological performance and may represent a useful approach for tissue acquisition in suspected PNETs, although the certainty of evidence remains limited.