Related Experiment Video
Updated: Aug 5, 2026
09:02
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Lactate-to-Albumin Ratio for Predicting Post-Contrast Acute Kidney Injury After Contrast-Enhanced CT in the Emergency
Mehmet Yortanlı1, Betül Çiğdem Yortanlı2, Ekrem Taha Sert3
1Department of Emergency Medicine, Konya Numune Hospital, Konya, Turkey.
Clinical and Experimental Emergency Medicine
|July 28, 2026
Summary
The lactate-to-albumin ratio (LAR) can predict post-contrast acute kidney injury (PC-AKI) after CT scans in the emergency department. LAR showed better accuracy than other ratios for identifying patients at risk of PC-AKI.
Area of Science:
- Nephrology
- Radiology
- Emergency Medicine
Background:
- Post-contrast acute kidney injury (PC-AKI) is a significant complication following contrast-enhanced computed tomography (CT).
- Early identification of patients at risk for PC-AKI is crucial for timely intervention and management.
- Biomarker ratios are being investigated for their potential in predicting PC-AKI.
Purpose of the Study:
- To evaluate the association between the lactate-to-albumin ratio (LAR) and PC-AKI development.
- To compare the discriminative performance of LAR with other biomarker ratios (BAR, CAR, NLR) in patients undergoing contrast-enhanced CT in the emergency department (ED).
Main Methods:
- Retrospective observational study of adult patients undergoing contrast-enhanced CT in a tertiary ED.
- Calculation of LAR, BAR, CAR, and NLR using laboratory values at ED presentation.
- Logistic regression analyses and receiver operating characteristic (ROC) curve analysis to assess predictive performance.
Main Results:
- PC-AKI occurred in 6.2% of 695 patients.
- LAR, BAR, and NLR were significantly associated with PC-AKI in multivariable analysis.
- LAR demonstrated the highest discriminative performance (AUC=0.854) compared to other ratios.
Conclusions:
- The lactate-to-albumin ratio (LAR) is associated with PC-AKI development after contrast-enhanced CT.
- LAR shows superior discriminative ability compared to other evaluated ratios.
- LAR may serve as a valuable tool for risk stratification of PC-AKI in the ED setting.
Related Concept Videos
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
01:22Acute Kidney Injury I: Introduction
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
01:30Radiological Investigation I: X-ray and CT
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and the...
01:20Acute Kidney Injury V: Interprofessional Care
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
01:28Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
01:27Imaging Studies III: Computed Tomography
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...