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Updated: Aug 5, 2026
14:20
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Innovative Therapeutic Strategies for Hormone-sensitive Breast Cancer: A Patent Landscape Review
Calinca Eliotério Oliveira1, José Adão Carvalho Nascimento Júnior2, Camila Rangel Santos3
1Postgraduate Program in Pharmacy, State University of Bahia, Salvador, Bahia, Brazil.
Recent Patents on Anti-Cancer Drug Discovery
|July 28, 2026
Summary
Innovative patents for hormone receptor-positive breast cancer focus on CDK4/6 and PIK3CA inhibitors to overcome endocrine resistance and advance precision oncology. Future research needs to address treatment side effects.
Area of Science:
- Oncology
- Pharmacology
- Intellectual Property Law
Background:
- Hormone receptor-positive (HR+) breast cancer presents significant therapeutic challenges due to endocrine resistance and disease progression.
- The patent landscape offers insights into innovative strategies for managing HR+ breast cancer.
Purpose of the Study:
- To investigate the patent landscape of novel pharmacological strategies for HR+ breast cancer.
- To identify emerging targets, technological trends, and their clinical development alignment.
Main Methods:
- Searched European Patent Office databases using keywords 'breast cancer and hormone therapy' and IPC code A61K.
- Included analysis of clinical trials for drug development and approval.
Main Results:
- 25 patents were selected, highlighting CDK4/6 inhibitors for tumor control and endocrine resistance.
- PIK3CA inhibitors show promise for patients with common HR+ breast cancer mutations.
Conclusions:
- Technological advancements emphasize targeted therapies, precision oncology, and overcoming endocrine resistance.
- Innovations drive personalized systemic therapies, but managing adverse effects remains an unmet need.
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