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Exploring the Relationship Between Hearing Loss and Cognitive Dysfunction from the Perspective of Molecular
Lu Wang1,2, Ziqi Zhou1,2, Xingqian Shen1,2
1Department of Otorhinolaryngology-Head and Neck Surgery, ENT Institute, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
None:
Dementia is primarily characterized by cognitive dysfunction, which is one of the major causes of disability. As hearing loss has been identified as the largest modifiable risk factor for dementia, understanding the intrinsic relationship between the two is crucial for preventing and mitigating the progression of dementia. A body of research has demonstrated a close association between hearing loss and morphological changes in the brain; however, the underlying molecular mechanisms require further elucidation. This review synthesizes current evidence on tau protein, amyloid beta protein, glutamate, gamma-aminobutyric acid, reactive oxygen species, and brain-derived neurotrophic factor to clarify potential molecular pathways linking hearing loss with cognitive dysfunction and to identify candidate targets for future mechanistic and translational studies.
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