Cyclodextrin-Based Delivery Systems in Cosmeceuticals: Current Advances and Future Perspectives

Area of Science:

• Cosmeceutical science
• Drug delivery systems
• Materials science

Background:

• Cyclodextrins (CDs) are cyclic carbohydrates forming inclusion complexes, improving molecule solubility, stability, and bioavailability.
• Traditionally used in food, their cosmeceutical applications are underexplored despite demand for advanced skincare.
• CDs offer potential solutions for formulation challenges in high-performance skincare.

Purpose of the Study:

• To provide an evidence-based overview of cyclodextrins in cosmeceuticals.
• To evaluate their role as carriers for active ingredients and in treating dermatological conditions.
• To discuss limitations and future perspectives for cyclodextrin innovation in skincare.

Main Methods:

• Review of in vitro, in vivo, and clinical studies on cyclodextrin complexation.
• Focus on active ingredients like vitamins A & C, coenzyme Q10, kojic acid, arbutin, and UV filters.
• Examination of cyclodextrins in treating acne, psoriasis, and rosacea, often with azelaic and salicylic acids.

Main Results:

• Cyclodextrin complexation enhances solubility, stability, controlled release, and skin penetration of active ingredients.
• Reduced adverse reactions observed with cyclodextrin-encapsulated actives.
• Potential therapeutic benefits demonstrated for dermatological conditions like acne, psoriasis, and rosacea.

Conclusions:

• Cyclodextrins are promising, safe, and effective multifunctional carriers for advanced cosmeceutical formulations.
• Further research into modified cyclodextrins and nanotechnology integration can unlock broader skincare applications.
• Addressing cost, solubility, and regulatory challenges is key for wider implementation.