Clinicopathological Characteristics of Odontogenic Keratocysts in the Mexican Population

Background/Objectives: Our aim is to describe the clinical, imaging, and histopathological features of odontogenic keratocyst in a Mexican cohort. Methods: This is a retrospective, descriptive, and cross-sectional study. Clinical records and histopathology reports (2015-2025) from multiple laboratories were reviewed. Slides stained with hematoxylin and eosin were evaluated by pathologists using standardized criteria. Descriptive statistics were performed. Results: A total of 106 cases were included. Ages ranged from 10 to 86 years (mean 33.4 ± 17.7). There was a predominance of males (61/106; 57.5%). The most frequent location was the posterior mandible (49/106; 46.2%), followed by anterior mandible (30/106; 28.3%), posterior maxilla (19/106; 17.9%), and anterior maxilla (8/106; 7.5%). Most cases were asymptomatic (73/106; 68.9%). Association with an impacted tooth was documented in 37/106 (34.9%) and root resorption in 26/106 (24.5%). Satellite epithelial islands were observed in 8/106 (7.5%), satellite cysts in 17/106 (16.0%), and both findings in 4/106 (3.8%). Chronic inflammation was present in 62/106 (58.5%). Conclusions: In this Mexican series, odontogenic keratocyst predominated in males and, in the posterior mandible, was frequently asymptomatic, and showed satellite foci and chronic inflammation in a relevant proportion, reinforcing the need for clinical-imaging and histopathological correlation, as well as follow-up.