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Biodegradable Temporizing Matrix for Facial Reconstruction Following Mohs Micrographic Surgery: A Multi-Subunit
Alexandra L Martinez1, James F Thornton1
1Department of Plastic Surgery, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Bioengineering (Basel, Switzerland)
|July 28, 2026
Summary
Biodegradable Temporizing Matrix (BTM) effectively aids facial reconstruction after Mohs surgery, promoting healing without skin grafts across nasal, periocular, and scalp areas. Further studies are recommended to confirm these positive outcomes.
Area of Science:
- Dermatology
- Plastic Surgery
- Regenerative Medicine
Background:
- Biodegradable Temporizing Matrix (BTM) is a synthetic polyurethane dermal substitute.
- BTM promotes neodermis formation and re-epithelialization.
- Limited data exists on BTM's performance in diverse facial subunit reconstructions.
Purpose of the Study:
- To systematically evaluate BTM performance in facial reconstruction across nasal, periocular, and scalp subunits.
- To characterize healing times, complication rates, and functional outcomes of BTM use.
- To assess BTM's utility as a definitive coverage, temporizing agent, or lining adjunct.
Main Methods:
- Retrospective case series of 135 patients undergoing facial reconstruction with BTM post-Mohs micrographic surgery (MMS).
- Data collected included patient demographics, defect characteristics, healing duration, complications, and secondary procedures.
- Analysis focused on outcomes across nasal, periocular, and scalp subunits.
Main Results:
- 135 patients included: 67 nasal, 40 periocular, 28 scalp reconstructions.
- Overall complication rates: 7.5% (nasal), 20.0% (periocular), 17.9% (scalp).
- Most patients achieved definitive coverage via secondary intention without skin grafting; lower eyelid and prior radiation predicted complications.
Conclusions:
- BTM shows favorable outcomes in facial reconstruction for nasal, periocular, and scalp defects post-MMS.
- BTM reliably supports secondary re-epithelialization and serves multiple reconstructive roles.
- Prospective comparative studies are necessary to validate these findings.
