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Tranilast Modulates Cellular and Matrix Remodeling in Achilles Tendon Healing: A Comprehensive Histological and
Oktay Adanır1, Ozancan Bicer1, Yigit Guleryuz2
1Department of Orthopedics and Traumatology, Bagcilar Training and Research Hospital, University of Health Sciences, Istanbul 34200, Turkey.
Bioengineering (Basel, Switzerland)
|July 28, 2026
Summary
Tranilast improved Achilles tendon healing histopathology but did not enhance biomechanical strength or collagen composition in rats within 30 days. Further studies are needed to confirm functional benefits.
Area of Science:
- Orthopedics
- Regenerative Medicine
- Pharmacology
Background:
- Tranilast is an anti-inflammatory and antifibrotic agent.
- Its effects on tendon healing are unknown.
- This study investigates tranilast's impact on Achilles tendon repair.
Purpose of the Study:
- To evaluate the histopathological and biomechanical effects of tranilast in a rat Achilles tendon repair model.
- To assess tranilast's influence on cellular morphology, matrix organization, and collagen composition.
- To determine if tranilast improves biomechanical strength during tendon healing.
Main Methods:
- Thirty-two rats were divided into control and tranilast groups (30 mg/kg/day).
- Tendon healing was assessed via biomechanical testing and histological scoring (Bonar, Movin) at 15 and 30 days.
- Collagen type I/III analysis and Sirius Red staining were performed.
Main Results:
- Tranilast significantly improved histopathological scores (Bonar, Movin), reducing tenocyte degeneration and matrix disorganization (p < 0.01).
- No significant differences in biomechanical strength (maximum load to failure) were observed between groups (p = 0.3948).
- Collagen composition and polarization ratio remained unchanged by tranilast treatment.
Conclusions:
- Tranilast promotes favorable histopathological changes in Achilles tendon healing.
- These improvements did not translate to enhanced biomechanical strength or altered collagen composition within 30 days.
- Long-term studies are necessary to determine if tranilast confers functional tendon healing benefits.
