Feasibility Pilot of the LaceUp Compression-Weight Sleeve for Essential Tremor

Area of Science:

• Neurology
• Biomedical Engineering
• Rehabilitation Medicine

Background:

• Essential tremor (ET) significantly impacts quality of life, with current treatments offering limited efficacy for many patients.
• Novel, non-invasive interventions are needed to manage the disabling symptoms of essential tremor.

Purpose of the Study:

• To evaluate the feasibility and preliminary efficacy of LaceUp, a passive wearable device for essential tremor.
• To assess tremor reduction and functional outcomes using objective and subjective measures.

Main Methods:

• A feasibility study involving ten adults with essential tremor (ET).
• Participants completed tasks under baseline, unweighted sleeve, wrist weight, and LaceUp conditions.
• Outcome measures included inertial measurement unit (IMU) data, spiral and handwriting analysis, and patient-reported satisfaction.

Main Results:

• LaceUp demonstrated the largest median tremor-band power reduction (-32.9%) on the more-affected limb compared to other conditions.
• Six out of nine participants preferred LaceUp in a ranking task.
• Some participants reported continued use and satisfaction at follow-up, though findings are preliminary.

Conclusions:

• The LaceUp wearable sleeve is a feasible intervention for essential tremor, showing potential for tremor reduction.
• Further research is warranted to confirm efficacy, optimize device use, and establish its role in ET management.