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Updated: Aug 5, 2026

Analyzing the Communication Between Monocytes and Primary Breast Cancer Cells in an Extracellular Matrix Extract (ECME)-based Three-dimensional System
10:55

Analyzing the Communication Between Monocytes and Primary Breast Cancer Cells in an Extracellular Matrix Extract (ECME)-based Three-dimensional System

Published on: January 8, 2018

Extracellular Matrix Remodeling as a Mechanobiological Driver of Breast Cancer Aggressiveness: Comparative Oncology,

João Paulo Ruiz Lucio de Lima Parra1, Rodrigo Paolo Flores Abuná1, Matheus Henrique Hermínio Garcia1

  • 1Regenerative Medicine Laboratory "Carlos Augusto Camargo de Souza Baptista", Universidade de Marília (UNIMAR), Marília 17525-902, SP, Brazil.

Biology
|July 28, 2026
PubMed

Keywords:
YAP/TAZartificial intelligencebreast cancercomparative oncologyextracellular matrixlipidomicsmechanotransductionmetabolomicsmetastasisproteomicstumor microenvironment

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The Extracellular Matrix01:29

The Extracellular Matrix

Overview
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The Extracellular Matrix01:42

The Extracellular Matrix

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The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...