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Association of SCARB1 Polymorphisms with Coronary Artery Disease Risk: A Systematic Review and Meta-Analysis

Jinzhou Yu1, Qianyu Zhou2, Qiang Zhang1

  • 1School of Nursing and Health, Zhengzhou University, Zhengzhou 450001, China.

Genes
|July 28, 2026
PubMed

Insights

Genetic variants in the SCARB1 gene, specifically rs5888 and rs10846744, show potential links to coronary artery disease (CAD) risk. rs5888 is associated with lower CAD risk in males, while rs10846744 suggests a protective effect.

Area of Science:

  • Genetics
  • Cardiovascular Disease Research
  • Molecular Biology

Background:

  • Coronary artery disease (CAD) is a leading global health concern.
  • The lipid metabolism gene SCARB1 is implicated in CAD susceptibility, but evidence is conflicting.
  • Investigating SCARB1 polymorphisms offers insight into CAD risk factors.

Purpose of the Study:

  • To systematically evaluate the association between SCARB1 gene polymorphisms and CAD risk.
  • To clarify the role of specific SCARB1 variants (rs5888, rs4238001, rs10846744) in CAD development.
  • To explore potential sex-specific or ethnicity-based differences in these associations.

Main Methods:

  • Systematic literature search of major databases (PubMed, Embase, etc.) up to February 2026.
  • Inclusion of 12 case-control studies with 3947 CAD cases and 5076 controls.
  • Meta-analysis of SCARB1 polymorphisms (rs5888, rs4238001, rs10846744) using various genetic models and heterogeneity assessment (I²).

Main Results:

  • SCARB1 rs5888 showed no overall association with CAD, but a significantly lower risk in males with the TT genotype (OR=0.73).
  • No significant association was found for rs4238001 with CAD across all models.
  • SCARB1 rs10846744 demonstrated a significant inverse association with CAD risk (allelic OR=0.78, dominant OR=0.68).

Conclusions:

  • SCARB1 rs5888 exhibits a male-specific association with reduced CAD risk.
  • SCARB1 rs10846744 suggests a potentially protective role against CAD, warranting further investigation.
  • These findings contribute to understanding the genetic underpinnings of CAD.
Abstract

Keywords:
SCARB1coronary artery diseasegenetic polymorphismgenetic susceptibilitymeta-analysis

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